Influenza vaccination in consecutive pregnancies is not associated with an increased risk of prespecified adverse perinatal outcomes, according to a study published online September 19 in JAMA Network Open.
Darios Getahan, MD, MPH, of Kaiser Permanente Southern California in Pasadena, and colleagues conducted a retrospective cohort study to examine the association between seasonal influenza vaccination in consecutive pregnancies and adverse perinatal outcomes in individuals who had at least two consecutive singleton pregnancies. Data from 82,055 singleton pregnancies from January 1, 2004 to December 31, 2018 were included.
Overall, 54.7 percent of participants received the influenza vaccine in consecutive pregnancies. The researchers found that vaccination in consecutive pregnancies was not associated with an increased risk of preeclampsia or eclampsia, placental abruption, fever, preterm labor, premature rupture of membranes, chorioamnionitis, or small-for-gestational age birth compared with those who did not receive the vaccine in either pregnancies. The observed associations did not vary by pregnancy interval or type of vaccine.
“The findings provide a basis for recommending vaccination during pregnancy, regardless of the interval between two successive pregnancies or the type of vaccine,” the authors wrote.
Further information: Darios Getahun et al., “Safety of Seasonal Influenza Vaccine in Two Consecutive Pregnancies,” JAMA Network Open (2024). DOI: 10.1001/jamanetworkopen.2024.34857
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Citation: No perinatal risks observed from influenza vaccination in consecutive pregnancies (September 23, 2024) Retrieved September 23, 2024 from https://medicalxpress.com/news/2024-09-perinatal-influenza-vaccination-successive-pregnancies.html
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