Khaled M. Influenza (seasonal). 2024. https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal). World Health Organization. Accessed 25 Apr 2024.
Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2023–2024. Pediatrics. 2023;152: e2023063773.
Young BE, Chen M. Influenza in temperate and tropical Asia: a review of epidemiology and vaccinology. Hum Vaccin Immunother. 2020;16:1659–67.
Google Scholar
Ilya K. Managing seasonal vaccination policies and coverage in the European region. 2014. https://www.who.int/europe/activities/managing-seasonal-vaccination-policies-and-coverage-in-the-european-region. WHO Task Force for Global Health. Accessed 16 Apr 2024.
Al Awaidi S, Abusrewil S, AbuHasan M, Akcay M, Aksakal FNB, Bashir U, Elahmer O, Esteghamati A, Gahwagi M, Mirza YK, et al. Influenza vaccination situation in Middle-East and North Africa countries. Report of the 7th MENA Influenza Stakeholders Network (MENA-ISN). J Infect Public Health. 2018;11:845–50.
Google Scholar
Hirve S. Seasonal influenza vaccine use in low and middle income countries in the tropics and subtropics. A systematic review. Geneva: Department of pandemic and epidemic diseases, World Health Organization; 2015.
McMahon AW, Iskander JK, Haber P, Braun MM, Ball R. Inactivated influenza vaccine (IIV) in children <2 years of age: Examination of selected adverse events reported to the vaccine adverse event reporting system (VAERS) after thimerosal-free or thimerosal-containing vaccine. Vaccine. 2008;26:427–9.
Google Scholar
Chung JR, Flannery B, Thompson MG, Gaglani M, Jackson ML, Monto AS, Nowalk MP, Talbot HK, Treanor JJ, Belongia EA, et al. Seasonal effectiveness of live attenuated and inactivated influenza vaccine. Pediatrics. 2016;137: e20153279.
Google Scholar
Becker T, Elbahesh H, Reperant LA, Rimmelzwaan GF, Osterhaus ADME. Influenza vaccines: successes and continuing challenges. J Infect Dis. 2021;224:S405–19.
Google Scholar
Jhaveri R. Live attenuated influenza vaccine: is past performance a guarantee of future results? Clin Ther. 2018;40:1246–54.
Google Scholar
Ray R, Dos Santos G, Buck PO, Claeys C, Matias G, Innis BL, Bekkat-Berkani R. A review of the value of quadrivalent influenza vaccines and their potential contribution to influenza control. Hum Vaccin Immunother. 2017;13:1640–52.
Google Scholar
European Medicines Agency ETF. Replacement of quadrivalent seasonal influenza vaccines with trivalent vaccines in the EU, Removal of antigens from B/Yamagata lineage. Amsterdam: European Medicines Agency; 2024. https://www.ema.europa.eu/en/documents/other/replacement-quadrivalent-seasonal-influenza-vaccines-trivalent-vaccines-eu_en.pdf Accessed 15 Apr 2024.
US food and drug administration. Use of trivalent influenza vaccines for the 2024–2025 U.S. Influenza season. 2024. https://www.fda.gov/vaccines-blood-biologics/lot-release/use-trivalent-influenza-vaccines-2024-2025-us-influenza-season. Accessed 28 Apr 2024.
World Health Organization. Recommendations announced for influenza vaccine composition for the 2024–2025 northern hemisphere influenza season. 2024. https://www.who.int/news/item/23-02-2024-recommendations-announced-for-influenza-vaccine-composition-for-the-2024-2025-northern-hemisphere-influenza-season. Accessed 28 Apr 2024.
European centre for disease prevention and control. Influenza: recommended vaccinations. 2023. https://vaccine-schedule.ecdc.europa.eu/Scheduler/ByDisease?SelectedDiseaseId=15&SelectedCountryIdByDisease=-1. Accessed 8 Dec 2023.
Nogareda F, Gharpure R, Contreras M, Velandia M, Lucia Pacis C, Elena Chevez A, Azziz-Baumgartner E, Salas D. Seasonal influenza vaccination in the Americas: progress and challenges during the COVID-19 pandemic. Vaccine. 2023;41:4554–60.
Google Scholar
Therapeutic Goods Administration, Australian Government, Department of Health and Aged Care. 2024 seasonal influenza vaccines, information for consumers and health professionals. 2024. https://www.tga.gov.au/resources/publication/publications/2024-seasonal-influenza-vaccines. Accessed 28 Apr 2024.
Li J, Zhang Y, Hang X, Liu L. Influenza and universal vaccine research in China. Viruses. 2022;15:116.
Google Scholar
Goldman RD, McGregor S, Marneni SR, Katsuta T, Griffiths MA, Hall JE, Seiler M, Klein EJ, Cotanda CP, Gelernter R, et al. Willingness to vaccinate children against influenza after the Coronavirus disease 2019 pandemic. J Pediatr. 2021;228:87-93.e82.
Google Scholar
Harris E. FDA will evaluate first self-administered FluMist vaccine. JAMA. 2023;330:1945–1945.
Google Scholar
De Gioia ER, Porqueddu A, Nebiaj O, Bianconi A, Conni A, Montalti M, Pandolfi P, Todeschini R, Fantini MP, Gori D. The role of needle fear in pediatric flu vaccine hesitancy. A cross-sectional study in Bologna metropolitan area. Vaccines (Basel). 2022;10:1388.
Google Scholar
Bambery B, Douglas T, Selgelid MJ, Maslen H, Giubilini A, Pollard AJ, Savulescu J. Influenza vaccination strategies should target children. Public Health Ethics. 2017;11:221–34.
Google Scholar
Minozzi S, Lytras T, Gianola S, Gonzalez-Lorenzo M, Castellini G, Galli C, Cereda D, Bonovas S, Pariani E, Moja L. Comparative efficacy and safety of vaccines to prevent seasonal influenza: a systematic review and network meta-analysis. EClinicalMedicine. 2022;46: 101331.
Google Scholar
Guo J, Chen X, Guo Y, Liu M, Li P, Tao Y, Liu Z, Yang Z, Zhan S, Sun F. Real-world effectiveness of seasonal influenza vaccination and age as effect modifier: a systematic review, meta-analysis and meta-regression of test-negative design studies. Vaccine. 2024;42:1883–91.
Google Scholar
World Health Organization. Global influenza strategy 2019–2030. Geneva: WHO; 2019. https://iris.who.int/bitstream/handle/10665/311184/9789241515320-eng.pdf?sequence=18. Accessed 26 Apr 2024.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Med. 2021. https://doi.org/10.1371/journal.pmed.1003583.
Google Scholar
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016;5:210.
Google Scholar
Randomized controlled trial of FluMist vs. Flucelvax. 2019. https://clinicaltrialsgov/show/. Accessed 10 Jan 2022.
Hoft DF, Babusis E, Worku S, Spencer CT, Lottenbach K, Truscott SM, Abate G, Sakala IG, Edwards KM, Creech CB, et al. Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children. J Infect Dis. 2011;204:845–53.
Google Scholar
Jefferson T, Rivetti A, Di Pietrantonj C, Demicheli V. Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev. 2018. https://doi.org/10.1002/14651858.CD004879.pub5.
Google Scholar
Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. JNCI J Natl Cancer Inst. 1959;22:719–48.
Google Scholar
Robins J, Greenland S, Breslow NE. A general estimator for the variance of the Mantel-Haenszel odds ratio. Am J Epidemiol. 1986;124:719–23.
Google Scholar
Paule RC, Mandel J. Consensus values and weighting factors. J Res Natl Bur Stand. 1977;1982(87):377–85.
Hartung J, Knapp G. A refined method for the meta-analysis of controlled clinical trials with binary outcome. Stat Med. 2001;20:3875–89.
Google Scholar
Harrer M, Cuijpers P, Furukawa TA, Ebert DD. Doing meta-analysis with r: a hands-on guide. 1st ed. Boca Raton: Chapman & Hall/CRC Press; 2021.
A randomized double-blind trial to assess the safety and realtive efficacy of CAIV-T against inactivated influenza vaccine in children 6–59 months of age. 2005. http://www.whoint/trialsearch/Trial2aspx?TrialID=EUCTR2004-000585-13-IT. Accessed 10 Jan 2022.
Belshe RB, Edwards KM, Vesikari T, Black SV, Walker RE, Hultquist M, Kemble G, Connor EM, Group C-TCES. Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med. 2007;356:685–96.
Google Scholar
Ilyushina NA, Haynes BC, Hoen AG, Khalenkov AM, Housman ML, Brown EP, Ackerman ME, Treanor JJ, Luke CJ, Subbarao K, Wright PF. Live attenuated and inactivated influenza vaccines in children. J Infect Dis. 2015;211:352–60.
Google Scholar
Effect of age and prior immunity to response to seasonal influenza vaccines in children. 2010. https://clinicaltrials.gov/show/NCT01246999. Accessed 10 Jan 2022.
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA. Cochrane handbook for systematic reviews of interventions version 6.3. 2022. www.training.cochrane.org/handbook. Accessed 22 May 2022.
GRADE handbook for grading quality of evidence and strength of recommendations. 2013. The GRADE working group. www.guidelinedevelopment.org/handbook. Accessed 22 May 2022.
Nypaver C, Dehlinger C, Carter C. Influenza and influenza vaccine. A review. J Midwifery Womens Health. 2021;66:45–53.
Google Scholar
Matrajt L, Halloran ME, Antia R. Successes and failures of the live-attenuated influenza vaccine: can we do better? Clin Infect Dis. 2019;70:1029–37.
Google Scholar
Mohn KG, Smith I, Sjursen H, Cox RJ. Immune responses after live attenuated influenza vaccination. Hum Vaccin Immunother. 2018;14:571–8.
Google Scholar
Randomized study of immune response to licensed influenza vaccines in children and adolescents. 2014. https://clinicaltrials.gov/show/NCT02250274. Accessed 10 Jan 2022.
Fleming DM, Crovari P, Wahn U, Klemola T, Schlesinger Y, Langussis A, Oymar K, Garcia ML, Krygier A, Costa H, et al. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J. 2006;25:860–9.
Google Scholar
Safety of LAIV4 in children with asthma. 2018.https://clinicaltrials.gov/show/NCT03600428. Accessed 10 Jan 2022.
Study of live, attenuated influenza vaccination in preterm and full-term infants. 2010. https://clinicaltrials.gov/show/NCT01194297. Accessed 10 Jan 2022.
Sokolow AG, Stallings AP, Kercsmar C, Harrington T, Jimenez-Truque N, Zhu Y, Sokolow K, Moody MA, Schlaudecker EP, Walter EB, et al. Safety of live attenuated influenza vaccine in children with asthma. Pediatrics. 2022;149: e2021055432.
Google Scholar
Luce BR, Nichol KL, Belshe RB, Frick KD, Li SX, Boscoe A, Rousculp MD, Mahadevia PJ. Cost-effectiveness of live attenuated influenza vaccine versus inactivated influenza vaccine among children aged 24–59 months in the United States. Vaccine. 2008;26:2841–8.
Google Scholar
Tarride JE, Burke N, Von Keyserlingk C, O’Reilly D, Xie F, Goeree R. Cost-effectiveness analysis of intranasal live attenuated vaccine (LAIV) versus injectable inactivated influenza vaccine (TIV) for Canadian children and adolescents. Clinicoecon Outcomes Res. 2012;4:287–98.
Google Scholar
Smolen LJ, Klein TM, Bly CA, Ryan KJ. Cost-effectiveness of live attenuated versus inactivated influenza vaccine among children. Am J Pharm Benefits. 2014;6:171–82.
Krishnan A, Dar L, Saha S, Narayan VV, Kumar R, Kumar R, Amarchand R, Dhakad S, Chokker R, Choudekar A, et al. Efficacy of live attenuated and inactivated influenza vaccines among children in rural India: a 2-year, randomized, triple-blind, placebo-controlled trial. PLoS Med. 2021;18: e1003609.
Google Scholar
Loeb M, Russell ML, Manning V, Fonseca K, Earn DJ, Horsman G, Chokani K, Vooght M, Babiuk L, Schwartz L, et al. Live attenuated versus inactivated influenza vaccine in hutterite children: a cluster randomized blinded trial. Ann Intern Med. 2016;165:617–24.
Google Scholar
Kissling E, Maurel M, Emborg HD, Whitaker H, McMenamin J, Howard J, Trebbien R, Watson C, Findlay B, Pozo F, et al. Interim 2022/23 influenza vaccine effectiveness: six European studies, October 2022 to January 2023. Euro Surveill. 2023;28:2300116.
Google Scholar
Huang C, Fu X, Zhou Y, Mi F, Tian G, Liu X, Wu J, Ding C, Yan D, Li L, Yang S. Comparison of the immunogenicity and safety of quadrivalent and tetravalent influenza vaccines in children and adolescents. Vaccine. 2020;38:1332–44.
Google Scholar
Miller ER, Moro PL, Cano M, Shimabukuro TT. Deaths following vaccination: what does the evidence show? Vaccine. 2015;33:3288–92.
Google Scholar
Ashkenazi S, Vertruyen A, Aristegui J, Esposito S, McKeith DD, Klemola T, Biolek J, Kuhr J, Bujnowski T, Desgrandchamps D, et al. Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. Pediatr Infect Dis J. 2006;25:870–9.
Google Scholar
Bandell A, Ambrose CS, Maniaci J, Wojtczak H. Safety of live attenuated influenza vaccine (LAIV) in children and adults with asthma: a systematic literature review and narrative synthesis. Expert Rev Vaccines. 2021;20:717–28.
Google Scholar
Boddington NL, Mangtani P, Zhao H, Verlander NQ, Ellis J, Andrews N, Pebody RG. Live-attenuated influenza vaccine effectiveness against hospitalization in children aged 2–6 years, the first three seasons of the childhood influenza vaccination program in England, 2013/14–2015/16. Influenza Other Respir Viruses. 2022;16:897–905.
Google Scholar
Peyrin-Biroulet L, Lopez A, Sandborn W. Head-to-head comparative studies: challenges and opportunities? J Crohns Colitis. 2016;11:S567–75.
Streiner DL. Alternatives to placebo-controlled trials. Can J Neurol Sci. 2007;34(Suppl 1):S37-41.
Google Scholar
Sackett DLSS, Richardson WS. Evidence-based medicine: how to practice and teach EBM. 2nd ed. Edinburgh: Churchill Livingstone; 2000.
Ainslie KEC, Haber M, Orenstein WA. Challenges in estimating influenza vaccine effectiveness. Expert Rev Vaccines. 2019;18:615–28.
Google Scholar
Ainslie KEC, Riley S. Is annual vaccination best? A modelling study of influenza vaccination strategies in children. Vaccine. 2022;40:2940–8.
Google Scholar
Shi X, Li KQ, Mukherjee B. Current challenges with the use of test-negative designs for modeling COVID-19 vaccination and outcomes. Am J Epidemiol. 2023;192:328–33.
Google Scholar
Pearson CAB, Edmunds WJ, Hladish TJ, Eggo RM. Potential test-negative design study bias in outbreak settings: application to Ebola vaccination in Democratic Republic of Congo. Int J Epidemiol. 2022;51:265–78.
Google Scholar
Saldanha IJ, Skelly AC, Ley KV, Wang Z, Berliner E, Bass EB, Devine B, Hammarlund N, Adam GP, Duan-Porter D, et al. AHRQ methods for effective health care. In: Saldanha IJ, editor., et al., Inclusion of nonrandomized studies of interventions in systematic reviews of intervention effectiveness: an update. Rockville: Agency for Healthcare Research and Quality; 2022.
Wen F, Guo J, Huang S. A meta-analysis identified genes responsible for distinct immune responses to trivalent inactivated and live attenuated influenza vaccines. J Cell Physiol. 2019;234:5196–202.
Google Scholar
Jefferson T, Rivetti A, Di Pietrantonj C, Demicheli V. Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev. 2018;2:Cd004879.
Google Scholar
Rosenthal NE, Carpenter CJ, James SP, Parry BL, Rogers SL, Wehr TA. Seasonal affective disorder in children and adolescents. Am J Psychiatry. 1986;143:356–8.
Google Scholar
Schrijver TV, Brand PL, Bekhof J. Seasonal variation of diseases in children: a 6-year prospective cohort study in a general hospital. Eur J Pediatr. 2016;175:457–64.
Google Scholar
Sterne JACSJ, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng H-Y, Corbett MS, Eldridge SM, Hernán MA, Hopewell S, Hróbjartsson A, Junqueira DR, Jüni P, Kirkham JJ, Lasserson T, Li T, McAleenan A, Reeves BC, Shepperd S, Shrier I, Stewart LA, Tilling K, White IR, Whiting PF, Higgins JPT. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366: l4898.
Google Scholar
Hegyi P, Erőss B, Izbéki F, Párniczky A, Szentesi A. Accelerating the translational medicine cycle: the Academia Europaea pilot. Nat Med. 2021;27:1317–9.
Google Scholar
Troiano G, Nardi A. Vaccine hesitancy in the era of COVID-19. Public Health. 2021;194:245–51.
Google Scholar
Alonso WJ, Yu C, Viboud C, Richard SA, Schuck-Paim C, Simonsen L, Mello WA, Miller MA. A global map of hemispheric influenza vaccine recommendations based on local patterns of viral circulation. Sci Rep. 2015;5:17214.
Google Scholar
Koul PA, Koul HP. Redefining the influenza equator. Lancet Glob Health. 2022;10: e1388.
Google Scholar
Gács Z, Koltai J. Understanding parental attitudes toward vaccination: comparative assessment of a new tool and its trial on a representative sample in Hungary. Vaccines. 2006;2022:10.
Taddio A, Chambers CT, Halperin SA, Ipp M, Lockett D, Rieder MJ, Shah V. Inadequate pain management during routine childhood immunizations: the nerve of it. Clin Ther. 2009;31(Suppl 2):S152-167.
Google Scholar
Chan KS-K, Wong CH-L, Choi HCW. Cost-effectiveness of intranasal live-attenuated influenza vaccine for children: a systematic review. Vaccines. 2022;10:1466.
Google Scholar
Wang Q, Jin H, Yang L, Jin H, Lin L. Cost-effectiveness of seasonal influenza vaccination of children in China: a modeling analysis. Infect Dis Poverty. 2023;12:92.
Google Scholar
Kiseleva I. Current opinion in LAIV: a matter of parent virus choice. Int J Mol Sci. 2022;23:6815.
Google Scholar
Carr S, Allison KJ, Van De Velde LA, Zhang K, English EY, Iverson A, Daw NC, Howard SC, Navid F, Rodriguez-Galindo C, et al. Safety and immunogenicity of live attenuated and inactivated influenza vaccines in children with cancer. J Infect Dis. 2011;204:1475–82.
Google Scholar
Kwong JC, Pereira JA, Quach S, Pellizzari R, Dusome E, Russell ML, Hamid JS, Feinberg Y, Winter AL, Gubbay JB, et al. Randomized evaluation of live attenuated vs. inactivated influenza vaccines in schools (RELATIVES) pilot study: a cluster randomized trial. Vaccine. 2015;33:535–41.
Google Scholar
Levin MJ, Song LY, Fenton T, Nachman S, Patterson J, Walker R, Kemble G, Allende M, Hultquist M, Yi T, et al. Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children. Vaccine. 2008;26:4210–7.
Google Scholar
Neuzil KM, Dupont WD, Wright PF, Edwards KM. Efficacy of inactivated and cold-adapted vaccines against influenza A infection, 1985 to 1990: the pediatric experience. Pediatr Infect Dis J. 2001;20:733–40.
Google Scholar
A phase 2 study to evaluate immune responses of FluMist®. 2007. https://clinicaltrials.gov/show/NCT00461981. Accessed 10 Jan 2022.