The grant will lead to the creation of USDHub, a new research tool that integrates research and clinical data from hundreds of thousands of kidney stone patients of all ages.
PHILADELPHIA , Oct. 15, 2024 /PRNewswire/ — Researchers from Children’s Hospital of Philadelphia (CHOP) and Vanderbilt University Medical Center receive funding from the National Institutes of Health (NIH) to lead a five-year, multi-site project. A $7.37 million RC2 grant focused on kidney stone disease research across the United States.
Led by CHOP pediatric urologist Gregory Tashian, MD, MSc CE and Vanderbilt University Medical Center urologist Ryan See, MD, the goal of this initiative is to develop a new research study called the Urolithiasis Hub (USDHub). It is about establishing tools. It aggregates data from across healthcare systems and research networks into one comprehensive platform, pulling data from a cohort of more than 230,000 patients suffering from nephrolithiasis.
Urolithiasis is a painful disease that can cause great suffering to affected patients. According to the National Kidney Foundation, the prevalence of kidney stones in Americans is approximately 11%, and more than 500,000 patients are sent to the emergency room each year due to kidney stones. Although urinary tract and kidney stones are traditionally thought of as an adult diagnosis, pediatric kidney stones are becoming more common, and CHOP clinicians encounter these stones every day. To meet the unique needs of children with kidney stones, CHOP has established the Pediatric Kidney Stone Center, a multidisciplinary program within the Department of Urology and Nephrology that specializes solely in the dietary, medical, and surgical management of kidney stones. was established.
Little progress has been made in the diagnosis and management of urolithiasis, in part due to the lack of datasets containing clinically relevant information about patients with urolithiasis over their lifetime. To address these challenges, USDHub leverages medical expertise across adult and pediatric urology and nephrology, and combines informatics and AI to integrate CT images, clinical records, stone composition, and 24-hour Establish a new data resource containing clinically important information from urine. Laboratories not available in existing research databases.
“Although we now see this painful condition more frequently, urolithiasis was once rare and there is a lack of strong evidence to support treatment decisions in children.” said Tasian, CHOP Chair in Clinical Epidemiology of Urinary Diseases. “Opportunities exist both to expand the evidence base for kidney and urinary stone management and to improve the research process itself.”
In addition to the work led by Drs. Tasian of CHOP and Hsi of Vanderbilt, USDHub has two PCORnet clinical research networks with standardized electronic medical record data, STAR and PEDSnet, and others. Seven sites will be involved. In addition to CHOP and Vanderbilt University Medical Center, the USDHub site includes the University of North Carolina, Medical University of South Carolina, Duke University, Texas Children’s Hospital, Nationwide Children’s Hospital, Lurie Children’s Hospital of Chicago, and Cincinnati Children’s Hospital.
“USDHub will synergize our efforts and expertise across adult and pediatric stone disease, engage patients and caregivers in the design process, and collaborate to ensure our sustainable data access model meets patient needs. This will be an initiative of ours,” Tasian said. “This program will ultimately provide longitudinal data and eliminate reliance on single-center data sources that separate pediatric and adult patients. We think it has the potential to accelerate and improve significantly.”
This research was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (grant 1RC2DK140865-01).
About Children’s Hospital of Philadelphia:
Children’s Hospital of Philadelphia, a nonprofit charity, was founded in 1855 as the nation’s first children’s hospital. Through its long-standing commitment to providing excellent patient care, training a new generation of pediatric health professionals, and pioneering major research efforts, the hospital has fostered many discoveries that benefit children around the world. Ta. Its pediatric research program is one of the largest in the country. The facility provides advanced pediatric care close to home through the CHOP Care Network, which includes more than 50 primary care clinics, specialty care and surgical centers, urgent care centers, and community hospital affiliates throughout Pennsylvania and New Jersey. There is an established history of doing so. , as well as the Middleman Family Pavilion and its dedicated pediatric emergency department in King of Prussia. Additionally, because of its unique family-centered care and public service programs, Children’s Hospital of Philadelphia is recognized as a leading advocate for children and youth. For more information, please visit https://www.chop.edu.
Contact: Kayla Rebello
Children’s Hospital of Philadelphia
(610) 457-5916
Contikm@chop.edu
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SOURCE Children’s Hospital of Philadelphia
