Serious eye conditions can be associated with anxiety, depression, bipolar disorder, schizophrenia and other mood disorders in children and adolescents, according to a presentation at the American Academy of Ophthalmology (AAO) annual meeting in Chicago this weekend. It is said that it is related to
“Our patients are more than eyes. As part of a multidisciplinary medical team, we have the opportunity to talk to them about these symptoms, ask parents and children if they have symptoms, and make referrals.” said Stacey L. Pineres, MD, professor of ophthalmology and residency program director at the Stein Eye Institute at the David Geffen School of Medicine at the University of California, Los Angeles, said during his presentation.
Mr. Pineles discussed the work of Dr. Yun H. Lee, now a pediatric ophthalmologist in New York. He conducted an analysis of insurance claims data for children with strabismus. At the time, Lee was interning in ophthalmology at the University of California Stein Eye Institute in Los Angeles.
The results showed that the highest associations were with cataracts, anxiety, and schizophrenia. Congenital optic nerve disease, anxiety, schizophrenia. Strabismus (crossed eyes), anxiety, schizophrenia.
Mr. Lee collected claims data from the OptumLabs Data Warehouse, a longitudinal anonymized commercial insurance claims database of children with strabismus under the age of 19, between January 1, 2007 and December 31, 2017. conducted a cross-sectional review.
Strabismus affects 2% to 5% of children in the United States, or more than 1.5 million children. Children with strabismus often have poor vision. Patches and glasses can help, but if these efforts do not correct strabismus, surgery may be necessary.
Lee et al. evaluated 352,636 children with strabismus and 11,652,553 children with no diagnosed eye disease. They include anxiety disorders, depressive disorders, substance use or addictive disorders, ‘bipolar disorder’ (bipolar disorder and related disorders), and ‘schizophrenia’ (schizophrenia spectrum and other psychotic disorders). evaluated two mental illness diagnoses.
They found that, overall, children with strabismus had higher rates of psychiatric disorders included in their diagnosis, with the exception of substance use disorders. Children with strabismus were more likely to be diagnosed with anxiety, depression, bipolar disorder, or schizophrenia than children without strabismus.
Lee’s research was published in the journal JAMA Ophysical in March 2022.
“The risk of anxiety is particularly high after multivariate analysis,” Pineres said during the AAO session. “Children were twice as likely to have an anxiety disorder, or an odds ratio of 2.01. They were also more likely to have depression, with a 60% increased risk of bipolar disorder and schizophrenia.
Pineres also discussed research he conducted with Elana A. Meer, MBA, MD, an ophthalmology resident at the University of California, San Francisco. Pineles, Meer, et al. compared OptumLabs’ claims to mental illness in 180,297 children with serious eye conditions such as glaucoma, cataracts, congenital optic nerve disease, congenital retinal disease, and blindness/amblyopia. Relevance was evaluated.
They found that there was a statistically significant association between having at least one of five eye diseases and schizophrenia, anxiety, depression, bipolar disorder, but not substance use. They found an inverse association with disability.
They found that children with any of these five serious eye conditions had a 45% and 54% increased risk of anxiety and schizophrenia, respectively. Glaucoma patients had the highest risk for anxiety, with a 23% increased risk. Thirteen percent of glaucoma patients in the database had anxiety, compared with 6% of patients without eye disease. Pediatric cataract patients had a 57% higher risk of anxiety and a 65% higher risk of schizophrenia.
“The highest associations we want to keep in mind are cataracts and anxiety and schizophrenia, congenital optic nerve disease and anxiety and schizophrenia, amblyopia, and all the psychiatric disorders that we investigated. condition,” Pineres said.
The study was published in the American Journal of Optharmology in August 2022.
