October 30, 2024
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Important points:
Lifestyle habits such as diet and exercise were associated with an increased risk of stroke and dementia later in life. Further research is needed, including how factors such as race and ethnicity influence the association.
Cardiovascular health in middle-aged adults was significantly associated with the risk of poor brain health later in life, according to a study published in the journal Neurology.
“Brain health is paramount to everyone’s optimal well-being, allowing us to function at our highest level and stay adapted to the world,” said study author and senior citizen said Santiago Crocchiatti Tuozzo, MD, MHS, a postdoctoral fellow in clinical epidemiology. Aging-related research in the Department of Neurology at Yale University is described in a release related to the study.
A new study on brain and heart health found that cardiovascular health in middle-aged adults is significantly associated with the risk of poor brain health later in life. Image: Adobe Stock
The American Heart Association’s Life’s Essential 8 (LE8) summarizes the determinants of cardiovascular health, but the cumulative impact on brain health indicators is unknown. This score includes eight modifiable cardiovascular risk factors: blood pressure, blood sugar, cholesterol, BMI, smoking, physical activity, diet, and sleep duration. Factors are divided into three subcategories: optimal, intermediate, and poor.
Clocchiatti-Tuozzo and colleagues investigated the hypothesis that worsening LE8 profiles in middle-aged adults are associated with increased overall risk of the most relevant clinical factors contributing to poor brain health.
The researchers undertook a two-stage prospective study that brought together data from the UK Biobank (UKB) and All of Us (AoU). The former is from the United Kingdom, which enrolled more than 500,000 individuals between 2006 and 2010, and the latter is currently underway in the United States. The NIH has been conducting a cohort study since 2018, and currently 400,000 people are enrolled. The discovery phase included 316,127 UKB participants (mean age 56 years, 52% female) and the replication phase included 68,407 AoU participants (mean age 56 years, 60% female) .
LE8 scores were calculated for each individual component, and then each participant’s overall score was calculated as the unweighted average of the eight component scores. The researchers then divided the overall LE8 score into three subcategories based on the total score (<20 is poor cardiovascular health, 20-80 is intermediate, and >80 is optimal cardiovascular health). health).
The primary outcome of this study was a composite of stroke, dementia, or late-life depression, with additional covariate analyzes including demographic information collected at the baseline interview for each study.
Results show that over an average follow-up of 4.9 years during the discovery phase, the unadjusted risk of the composite outcome was 0.7% (95% CI 0.61-0.74) for optimal and 1.2% (95% CI 1.11-1.22) for optimal . intermediate, 1.8% (95% CI 1.70-1.91) for poor cardiovascular health, respectively;
The data further show that at 2.9 years of follow-up during the replication phase, the unadjusted risk for the composite outcome was 2.8% (95% CI 2.49-3.05) at best and 6% (95% CI 5.76-6.22) at mid-term. I showed that. 9.7% (95% CI 9.24 to 10.24) for poor cardiovascular health;
This association was associated with moderate cardiovascular health and optimal cardiovascular health (HR = 1.35; 95% CI, 1.21 to 1.51), and between poor cardiovascular health and optimal cardiovascular health. (HR = 1.94; 95% CI, 1.72 to 2.18) was maintained in the comparative analysis.
“Our findings highlight the potential brain health benefits of harnessing these eight cardiovascular and brain health factors to guide healthy lifestyle choices.” said Crochiatti Tuozzo in a release. “Further research is needed to understand the link between lifestyle and brain health, and how social factors such as race and ethnicity influence this association.”
reference:
Live well, think well: Research shows that healthy habits are linked to brain health. https://www.aan.com/PressRoom/Home/PressRelease/5208. Published October 24, 2024. Accessed October 28, 2024.
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