World Health Organization. Cardiovascular Disease (CVD) (Internet). 2025 (cited August 6, 2025); Available from https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).
World Health Organization. Obesity and overweight (Internet). 2025 (cited August 6, 2025); available at https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
World Health Organization. Diabetes (Internet). 2025 (cited August 6, 2025); available from https://www.who.int/news-room/fact-sheets/detail/diabetes.
Zhang, D. et al. Multimorbidity of cardiometabolic diseases: prevalence and mortality risk among 1 million Chinese adults in a longitudinal cohort study. BMJ Open 9, e024476 (2019).
Cheng, X. et al. Trends in the prevalence of cardiometabolic complex diseases in the United States (1999-2018). Int J. Environ. Res Public Health 19, 4726 (2022).
Ravi, CJ et al. Management of cardiovascular disease in obese patients. nut. Pastor Cardiol. 15, 45–56 (2018).
Roeters van Lennep, JE et al. Women, lipids, and atherosclerotic cardiovascular disease: A call to action from the European Atherosclerosis Society. EUR. Heart J. 44, 4157–4173 (2023).
Barker, DJP & Bagby, SP Antecedents of cardiovascular disease: A historical perspective. J.Am. Social Nephrol. 16, 2537–2544 (2005).
Cochrane, ALK, Murphy, MP, Ozanne, SE & Giussani, DA Mechanisms of increased cardiovascular risk in pregnancy and offspring in obese women. EUR. Heart J. 45, 5127–5145 (2024).
Guenard, F. et al. Differences in methylation in carbohydrate-regulated genes in offspring born before and after maternal gastrointestinal bypass surgery. PNAS 110, 11439–11444 (2013).
Van De Maele, K., Devlieger, R. & Gies, I. In utero programming and early detection of cardiovascular disease in offspring of obese mothers. Atherosclerosis 275, 182–195 (2018).
Smith, J. et al. Effects of maternal surgical weight loss on the intergenerational transmission of obesity. J. Clin. Endocrine. Metab. 94, 4275–4283 (2009).
Schonejans, JM & Ozanne, SE Developmental programming by maternal obesity: Lessons from animal models. Diabetes. medicine. 38, e14694 (2021).
Reynolds, CM, Vickers, MH Utility of small animal models for developmental programming (Internet). User: Guest PC, editor. Investigating early nutritional effects on long-term health: Methods and applications. New York, NY: Springer. 2018 (cited January 23, 2023). 145-163. Available from https://doi.org/10.1007/978-1-4939-7614-0_8.
Naoya Itani et al. High and low levels of programmed cardiovascular disease due to developmental hypoxia: Study on chicken embryos. J. Physiol. 596, 2991–3006 (2018).
Lombardo, SD, Wangsaputra, IF, Menche, J. & Stevens, A. A network approach to charting the transcriptomic and epigenetic landscape of the developmental origins of health and disease. Genes 13, 764 (2022).
Shasikadze, B. et al. Developmental effects of gestational (pre)diabetes on offspring: a systematic screen using an omics approach. Genes 12, 1991 (2021).
Ozen, M. et al. Omics approaches: interactions at the maternal-fetal interface and the origins of child health and disease. Pediatrics. Res 93, 366–375 (2023).
Fleury, ES et al. Evaluation of the neonatal umbilical cord serum metabolome in relation to adolescent cardiometabolic risk factors. Pediatrics. Res https://doi.org/10.1038/s41390-025-04322-4 (2025).
Fernandez-Twin, DS et al. Exercise restores insulin sensitivity in obese mothers, placental hypoxia, and insulin sensitivity in male infants. Science. Rep. 7, 44650 (2017).
Beeson, J.H. et al. Maternal exercise intervention for obese pregnancies improves cardiovascular health in adult male offspring. Mol. Metab. 16, 35–44 (2018).
Baden, SJ et al. Maternal obesity and cardiovascular remodeling in children – the impact of preconception and prenatal lifestyle interventions: a systematic review. Int J. Obes. 48, 1045–1064 (2024).
Rice, MM et al. Pregnancy-associated hypertension and cardiometabolic health in children. Ofstedt. Guinecole. 131, 313–321 (2018).
Yuan, WL et al. Adverse effects of maternal blood sugar during pregnancy on offspring cardiometabolic health profile. Acta Pediatr. 114, 2287–2297 (2025).