Qu QR, Tang LY, Liu Q, Long YY, Wu X, Xu M, et al. Proteomic Analysis of the Sphincter in a Neurogenic Bladder Caused by T10 Spinal Cord Injury. J Integr Neurosci. 2022;21:147.
Google Scholar
Li JA, Shi MP, Cong L, Gu MY, Chen YH, Wang SY, et al. Circulating exosomal lncRNA contributes to the pathogenesis of spinal cord injury in rats. Neural Regen Res. 2023;18:889–94.
Google Scholar
García-Rudolph A, Wright MA, Devilleneuve EA, Castillo E, Opisso E, Hernandez-Pena E. Pressure ulcers acquired during inpatient rehabilitation after spinal cord injury, characterization and predictors: A 15-years’ experience. NeuroRehabilitation. 2024;54:457–72.
Google Scholar
Cowan H, Lakra C, Desai M. Autonomic dysreflexia in spinal cord injury. BMJ. 2020;371:m3596.
Google Scholar
Chen YC, Kuo HC. Risk factors of video urodynamics and bladder management for long-term complications in patients with chronic spinal cord injury. Sci Rep. 2024;14:12632.
Google Scholar
Kumar R, Lim J, Mekary RA, Rattani A, Dewan MC, Sharif SY, et al. Traumatic Spinal Injury: Global Epidemiology and Worldwide Volume. World Neurosurg. 2018;113:e345–e363.
Google Scholar
Aschauer-Wallner S, Leis S, Bogdahn U, Johannesen S, Couillard-Despres S, Aigner L. Granulocyte colony-stimulating factor in traumatic spinal cord injury. Drug Discov Today. 2021;26:1642–55.
Google Scholar
Jiang B, Sun D, Sun H, Ru X, Liu H, Ge S, et al. Prevalence, Incidence, and External Causes of Traumatic Spinal Cord Injury in China: A Nationally Representative Cross-Sectional Survey. Front Neurol. 2021;12:784647.
Google Scholar
Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:459–80.
Freyermuth-Trujillo X, Segura-Uribe JJ, Salgado-Ceballos H, Orozco-Barrios CE, Coyoy-Salgado A. Inflammation: A Target for Treatment in Spinal Cord Injury. Cells. 2022;11:2692.
De la Garza Ramos R, Nakhla J, Nasser R, Jada A, Sciubba DM, Kinon MD, et al. The Impact of Hospital Teaching Status on Timing of Intervention, Inpatient Morbidity, and Mortality After Surgery for Vertebral Column Fractures with Spinal Cord Injury. World Neurosurg. 2017;99:140–4.
Google Scholar
Xu B, Fang J, Wang J, Jin X, Liu S, Song K, et al. Inhibition of autophagy and RIP1/RIP3/MLKL-mediated necroptosis by edaravone attenuates blood spinal cord barrier disruption following spinal cord injury. Biomed Pharmacother. 2023;165:115165.
Google Scholar
Seblani M, Decherchi P, Brezun JM. Edema after CNS Trauma: A Focus on Spinal Cord Injury. Int J Mol Sci. 2023;24:7159.
Ma D, Shen H, Chen F, Liu W, Zhao Y, Xiao Z, et al. Inflammatory Microenvironment-Responsive Nanomaterials Promote Spinal Cord Injury Repair by Targeting IRF5. Adv Health Mater. 2022;11:e2201319.
Xiao S, Zhang Y, Liu Z, Li A, Tong W, Xiong X, et al. Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2/STAT3 signaling pathway in spinal cord injury. CNS Neurosci Ther. 2023;29:1094–108.
Google Scholar
Clifford T, Finkel Z, Rodriguez B, Joseph A, Cai L. Current Advancements in Spinal Cord Injury Research-Glial Scar Formation and Neural Regeneration. Cells. 2023;12:853.
Lu Q, Botchway BOA, Zhang Y, Jin T, Liu X. SARM1 can be a potential therapeutic target for spinal cord injury. Cell Mol Life Sci. 2022;79:161.
Google Scholar
Zhou X, Wahane S, Friedl MS, Kluge M, Friedel CC, Avrampou K, et al. Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2. Nat Neurosci. 2020;23:337–50.
Google Scholar
Feng Y, Peng Y, Jie J, Yang Y, Yang P. The immune microenvironment and tissue engineering strategies for spinal cord regeneration. Front Cell Neurosci. 2022;16:969002.
Google Scholar
Jin LY, Li J, Wang KF, Xia WW, Zhu ZQ, Wang CR, et al. Blood-Spinal Cord Barrier in Spinal Cord Injury: A Review. J Neurotrauma. 2021;38:1203–24.
Google Scholar
Li W, Zhao X, Zhang R, Liu X, Qi Z, Zhang Y, et al. Ferroptosis inhibition protects vascular endothelial cells and maintains integrity of the blood-spinal cord barrier after spinal cord injury. Neural Regen Res. 2023;18:2474–81.
Google Scholar
Bretheau F, Castellanos-Molina A, Bélanger D, Kusik M, Mailhot B, Boisvert A, et al. The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury. Nat Commun. 2022;13:5786.
Google Scholar
Hirsch JE. Does the H index have predictive power? Proc Natl Acad Sci USA. 2007;104:19193–8.
Google Scholar
Earnhardt JN, Streit WJ, Anderson DK, O’Steen WA, Nick HS. Induction of manganese superoxide dismutase in acute spinal cord injury. J Neurotrauma. 2002;19:1065–79.
Google Scholar
Hu Q, Li Y, Lin Z, Zhang H, Chen H, Chao C, et al. The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury. Drug Des Devel Ther. 2024;18:1399–414.
Google Scholar
Loane DJ, Byrnes KR. Role of microglia in neurotrauma. Neurotherapeutics. 2010;7:366–77.
Google Scholar
Donnelly DJ, Longbrake EE, Shawler TM, Kigerl KA, Lai W, Tovar CA, et al. Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages. J Neurosci. 2011;31:9910–22.
Google Scholar
Li Y, Lei Z, Ritzel RM, He J, Li H, Choi HMC, et al. Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice. Theranostics. 2022;12:5364–88.
Google Scholar
Tang S, Botchway BOA, Zhang Y, Wang X, Huang M, Liu X. Resveratrol can improve spinal cord injury by activating Nrf2/HO-1 signaling pathway. Ann Anat. 2024;251:152180.
Google Scholar
Xie DM, Sun C, Tu Q, Li S, Zhang Y, Mei X, et al. Modified black phosphorus quantum dots promotes spinal cord injury repair by targeting the AKT signaling pathway. J Tissue Eng. 2023;14:20417314231180033.
Google Scholar
Schmidt J, Quintá HR. Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches. Neural Regen Res. 2023;18:2161–6.
Google Scholar
Yin Z, Wan B, Gong G, Yin J. ROS: Executioner of regulating cell death in spinal cord injury. Front Immunol. 2024;15:1330678.
Guo XD, He XG, Yang FG, Liu MQ, Wang YD, Zhu DX, et al. Research progress on the regulatory role of microRNAs in spinal cord injury. Regen Med. 2021;16:465–76.
Google Scholar
Zhang C, Kang J, Zhang X, Zhang Y, Huang N, Ning B. Spatiotemporal dynamics of the cellular components involved in glial scar formation following spinal cord injury. Biomed Pharmacother. 2022;153:113500.
Google Scholar
Kuhn S, Gritti L, Crooks D, Dombrowski Y. Oligodendrocytes in Development, Myelin Generation and Beyond. Cells. 2019;8:1424.
Shang Z, Shi W, Fu H, Zhang Y, Yu T. Identification of key autophagy-related genes and pathways in spinal cord injury. Sci Rep. 2024;14:6553.
Google Scholar
Liao H-Y, Wang Z-Q, Ran R, Zhou K-S, Ma C-W, Zhang H-H. Biological Functions and Therapeutic Potential of Autophagy in Spinal Cord Injury. Front Cell Dev Biol. 2021;9:761273.
Feng J, Zhang Y, Zhu Z, Gu C, Waqas A, Chen L. Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury. Front Cell Dev Biol. 2021;9:703989.
Singh N, Guha L, Kumar H. From hope to healing: Exploring the therapeutic potential of exosomes in spinal cord injury. Extracell Vesicle. 2024;3:100044.
Hirsch JE. An index to quantify an individual’s scientific research output. Proc Natl Acad Sci USA. 2005;102:16569–72.
Google Scholar
Detloff MR, Fisher LC, McGaughy V, Longbrake EE, Popovich PG, Basso DM. Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Exp Neurol. 2008;212:337–47.
Google Scholar
Fouad K, Popovich PG, Kopp MA, Schwab JM. The neuroanatomical-functional paradox in spinal cord injury. Nat Rev Neurol. 2021;17:53–62.
Google Scholar
Huang X, Cao Z, Qian J, Ding T, Wu Y, Zhang H, et al. Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptors. Nat Nanotechnol. 2024;19:545–53.
Google Scholar
Cohen M, Ben-Yehuda H, Porat Z, Raposo C, Gordon S, Schwartz M. Newly Formed Endothelial Cells Regulate Myeloid Cell Activity Following Spinal Cord Injury via Expression of CD200 Ligand. J Neurosci. 2017;37:972–85.
Google Scholar
Slater PG, Domínguez-Romero ME, Villarreal M, Eisner V, Larraín J. Mitochondrial function in spinal cord injury and regeneration. Cell Mol Life Sci. 2022;79:239.
Google Scholar
Fatima G, Sharma VP, Das SK, Mahdi AA. Oxidative stress and antioxidative parameters in patients with spinal cord injury: implications in the pathogenesis of disease. Spinal Cord. 2015;53:3–6.
Google Scholar
Bhat AH, Dar KB, Anees S, Zargar MA, Masood A, Sofi MA, et al. Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight. Biomed Pharmacother. 2015;74:101–10.
Google Scholar
Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, et al. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One. 2012;7:e46364.
Google Scholar
Brennan AM, Suh SW, Won SJ, Narasimhan P, Kauppinen TM, Lee H, et al. NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci. 2009;12:857–63.
Google Scholar
Zhang L, Wang H, Zhou X, Mao L, Ding K, Hu Z. Role of mitochondrial calcium uniporter-mediated Ca(2+) and iron accumulation in traumatic brain injury. J Cell Mol Med. 2019;23:2995–3009.
Google Scholar
Hu X, Xu Y, Xu H, Jin C, Zhang H, Su H, et al. Progress in Understanding Ferroptosis and Its Targeting for Therapeutic Benefits in Traumatic Brain and Spinal Cord Injuries. Front Cell Dev Biol. 2021;9:705786.
Google Scholar
Liu D, Liu J, Sun D, Wen J. The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction. J Neurotrauma. 2004;21:805–16.
Google Scholar
Taoka Y, Naruo M, Koyanagi E, Urakado M, Inoue M. Superoxide radicals play important roles in the pathogenesis of spinal cord injury. Paraplegia. 1995;33:450–3.
Google Scholar
Coyoy-Salgado A, Segura-Uribe JJ, Guerra-Araiza C, Orozco-Suárez S, Salgado-Ceballos H, Feria-Romero IA, et al. The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview. Oxid Med Cell Longev. 2019;2019:3642491.
Google Scholar
Zhang B, Bailey WM, McVicar AL, Gensel JC. Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury. Neurobiol Aging. 2016;47:157–67.
Google Scholar
Miao X, Lin J, Zheng X. Advances of the role of mitochondrial dysfunction in the spinal cord injury and its relevant treatments. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2022;36:902–7.
Google Scholar
Hall ED. Antioxidant therapies for acute spinal cord injury. Neurotherapeutics. 2011;8:152–67.
Google Scholar
Zhang C, Talifu Z, Xu X, Liu W, Ke H, Pan Y, et al. MicroRNAs in spinal cord injury: A narrative review. Front Mol Neurosci. 2023;16:1099256.
Google Scholar
Zhu Y, Xu Q, Sha WP, Zhao KP, Wang LM. MiR-219-5p promotes spinal cord injury recovery by inhibiting NEUROD2-regulated inflammation and oxidative stress. Eur Rev Med Pharm Sci. 2019;23:37–43.
Google Scholar
Wang R, Liu Y, Jing L. MiRNA-99a alleviates inflammation and oxidative stress in lipopolysaccharide-stimulated PC-12 cells and rats post spinal cord injury. Bioengineered. 2022;13:4248–59.
Google Scholar
Ding LZ, Xu J, Yuan C, Teng X, Wu QM. MiR-7a ameliorates spinal cord injury by inhibiting neuronal apoptosis and oxidative stress. Eur Rev Med Pharm Sci. 2020;24:11–7.
Jiang Y, Rong H, Wang Y, Liu S, Xu P, Luo Z, et al. Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection. Nano Res. 2023;16:9752–9.
Google Scholar
Li Y, Guo Y, Fan Y, Tian H, Li K, Mei X. Melatonin Enhances Autophagy and Reduces Apoptosis to Promote Locomotor Recovery in Spinal Cord Injury via the PI3K/AKT/mTOR Signaling Pathway. Neurochem Res. 2019;44:2007–19.
Google Scholar
Zhang Y, Zhang W-X, Zhang Y-J, Liu Y-D, Liu Z-J, Wu Q-C, et al. Melatonin for the treatment of spinal cord injury. Neural Regen Res. 2018;13:1685–92.
Google Scholar
Wang H, Wang H, Huang H, Qu Z, Ma D, Dang X, et al. Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome. Cells. 2022;11:2809.
Google Scholar
Bellver-Landete V, Bretheau F, Mailhot B, Vallières N, Lessard M, Janelle ME, et al. Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury. Nat Commun. 2019;10:518.
Google Scholar
Pearson CS, Mencio CP, Barber AC, Martin KR, Geller HM. Identification of a critical sulfation in chondroitin that inhibits axonal regeneration. eLife 2018;7:e37139.
Google Scholar
Wanner IB, Anderson MA, Song B, Levine J, Fernandez A, Gray-Thompson Z, et al. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J Neurosci. 2013;33:12870–86.
Google Scholar
Brennan FH, Li Y, Wang C, Ma A, Guo Q, Li Y, et al. Microglia coordinate cellular interactions during spinal cord repair in mice. Nat Commun. 2022;13:4096.
Google Scholar
Hackett AR, Lee JK. Understanding the NG2 Glial Scar after Spinal Cord Injury. Front Neurol. 2016;7:199.
Google Scholar
Ageeva T, Rizvanov A, Mukhamedshina Y. NF-κB and JAK/STAT Signaling Pathways as Crucial Regulators of Neuroinflammation and Astrocyte Modulation in Spinal Cord Injury. Cells. 2024;13:581.
Google Scholar
Lee JY, Park CS, Seo KJ, Kim IY, Han S, Youn I, et al. IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Exp Neurol. 2023;370:114576.
Google Scholar
Sun X, Liu H, Tan Z, Hou Y, Pang M, Chen S, et al. Remodeling Microenvironment for Endogenous Repair through Precise Modulation of Chondroitin Sulfate Proteoglycans Following Spinal Cord Injury. Small. 2023;19:e2205012.
Google Scholar
Chen T, He X, Wang J, Du D, Xu Y. NT-3 Combined with TGF-β Signaling Pathway Enhance the Repair of Spinal Cord Injury by Inhibiting Glial Scar Formation and Promoting Axonal Regeneration. Mol Biotechnol. 2024;66:1484–95.
Google Scholar
Inoue M, Yamaguchi R, He CCJ, Ikeda A, Okano H, Kohyama J. Current status and prospects of regenerative medicine for spinal cord injury using human induced pluripotent stem cells: a review. Stem Cell Investig. 2023;10:6.
Google Scholar
Gong W, Zhang T, Che M, Wang Y, He C, Liu L, et al. Recent advances in nanomaterials for the treatment of spinal cord injury. Mater Today Bio. 2023;18:100524.
Google Scholar
Xiong T, Yang K, Zhao T, Zhao H, Gao X, You Z, et al. Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment. Adv Sci. 2023;10:e2205997.
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol. 2009;10:458–67.
Google Scholar
Takeshige K, Baba M, Tsuboi S, Noda T, Ohsumi Y. Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J Cell Biol. 1992;119:301–11.
Google Scholar
Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, et al. A protein conjugation system essential for autophagy. Nature. 1998;395:395–8.
Google Scholar
Yamamoto H, Matsui T. Molecular Mechanisms of Macroautophagy, Microautophagy, and Chaperone-Mediated Autophagy. J Nippon Med Sch. 2024;91:2–9.
Google Scholar
Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018;19:349–64.
Google Scholar
Gao Y, Zorman S, Gundersen G, Xi Z, Ma L, Sirinakis G, et al. Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science. 2012;337:1340–3.
Google Scholar
Kim J, Kleizen B, Choy R, Thinakaran G, Sisodia SS, Schekman RW. Biogenesis of gamma-secretase early in the secretory pathway. J Cell Biol. 2007;179:951–63.
Google Scholar
Südhof TC, Rothman JE. Membrane fusion: grappling with SNARE and SM proteins. Science. 2009;323:474–7.
Google Scholar
Wang T, Huang G, Yi Z, Dai S, Zhuang W, Guo S. Advances in extracellular vesicle-based combination therapies for spinal cord injury. Neural Regen Res. 2024;19:369–74.
Google Scholar
Luo C, Tao L. The Function and Mechanisms of Autophagy in Spinal Cord Injury. Adv Exp Med Biol. 2020;1207:649–54.
Google Scholar
Zhang C, Li D, Hu H, Wang Z, An J, Gao Z, et al. Engineered extracellular vesicles derived from primary M2 macrophages with anti-inflammatory and neuroprotective properties for the treatment of spinal cord injury. J Nanobiotechnol. 2021;19:373.
Google Scholar