The San Francisco 49ers could bring back two of their top players in time for Week 4, and bettors may reconsider backing them at NFL picks in Week 4. The defending NFC champions have been plagued by injuries early in the season, but tight end George Kittle will be back on the field on Sunday, expected to ease Brock Purdy’s offense. Star receiver Deebo Samuel is still questionable to play at home against the New England Patriots, but he could also return for those who select the 49ers in their NFL projections.
San Francisco is a 10.5-point favorite in NFL odds, and bettors may have been shying away from it earlier this week due to mounting injuries. Given the potential return of Kittle and Samuel, should you reconsider backing the 49ers with a Week 4 NFL pick? All Week 4 NFL lines are listed below and on SportsLine Our advanced computer model has all the NFL betting advice and NFL predictions you need to make the best picks in the NFL for Week 4.
Since its inception, the model, which simulates every NFL game 10,000 times, has increased well over $7,000 for a $100 player with an A-rated NFL pick. The model enters Week 4 of the 2024 NFL season with an impressive 187-130 record among the NFL’s top-rated players dating back to the 2017 season. Since Week 7 of the 2022 NFL season, even A-rated NFL draft picks have gone 41-22.
The model has also ranked in NFLPickWatch’s top 10 for direct NFL picks in four of the last six years, beating over 94% of CBS Sports Football Pick ‘Em players four times during that time. Anyone who follows it has improved considerably.
We’re currently focusing on the latest Week 4 NFL odds and NFL betting lines for the spread, money line, over-under, and locking in our picks for every NFL game. To see all our picks, go here.
NFL Week 4 Top Predictions
One of the model’s strongest Week 4 NFL picks is arguably the Saints (+2.5, 41.5) covering the spread against the Falcons. New Orleans has been very successful in this series, winning 10 of the last 13 meetings with Atlanta. The Saints have also been very good as road underdogs, going 5-1 ATS in their last six games against home favorites.
The Saints’ offense has been particularly effective so far this season, with Derek Carr completing 68% of his passes and Alvin Kamara gaining 285 rushing yards with four touchdowns. The Falcons have the league’s 28th-ranked rushing defense, so Carr should feel comfortable handing the ball off to his veteran running back to help lead the Saints to the end zone. Find out which other teams to choose here.
Another NFL betting prediction for Week 4: Steelers (-2, 40) cover on the road vs. Colts. Pittsburgh’s run defense slowed down Chargers running back J.K. Dobbins last week, holding him to just 44 yards on 15 attempts. They will now face Colts running back Jonathan Taylor. Jonathan Taylor leads the rushing attack averaging 5.4 yards per carry.
Steelers edge rusher TJ Watt has 5.5 sacks, four tackles for loss, 15 tackles for loss and two forced fumbles in five career games against the Colts. He had two sacks and two tackles for loss in his most recent matchup (Week 15 of last season), and is on pace to reach 100 career sacks, second only to Reggie White. SportsLine’s model projects Watt to be disruptive again on Sunday, which is one reason the Steelers cover the spread well above 50% of simulations. Find out which other teams to choose here.
How to make your Week 4 NFL picks.
The model also looks at who will win and cover every other game on the NFL Week 4 schedule, revealing three teams with at least a 70% chance of winning outright and potentially earning a huge payday. I made it. Only SportsLine has all the picks for every game.
So which NFL player can you pick with confidence? Which are the three must-watch teams to keep an eye on right now? Check out the latest NFL odds below, then visit SportsLine , see which team wins and covers the spread. Find out, all from proven computer models that have earned well over $7,000.
Week 4 NFL betting odds, lines and spreads
Get your Week 4 NFL picks on SportsLine
Sunday, September 29th
Saints at Falcons (-2.5, 41.5)
Bengals vs. Panthers (+4.5, 47)
Rams vs. Bears (-3, 40.5)
Vikings vs. Packers (-3, 44)
Jaguars vs. Texans (-5.5, 44.5)
Steelers vs. Colts (+2, 40)
Broncos vs. Jets (-8, 39.5)
Eagles vs. Buccaneers (+1, 42)
Cardinals manager (-3.5, 49)
Patriots vs. 49ers (-10.5, 40.5)
Browns vs. Raiders (+2.5, 36.5)
Chiefs at Chargers (+7, 41.5)
Bills at Ravens (-2.5, 46.5)
Monday, September 30th
Titans vs. Dolphins (-2.5, 37)
Seahawks vs. Lions (-3.5, 46.5)
