NFL injuries often come in waves, but a huge wave hit the league last week. Several stars were injured, but perhaps no game on the NFL schedule in Week 3 will be more injury-impacted than the 49ers vs. Rams. San Francisco originally started as a 4.5-point favorite and is now a 6.5-point favorite. Injuries to Cooper Kupp, Puka Nacua, and three offensive linemen on the Rams outweigh the injuries to Christian McCaffrey and Deebo Samuel on the 49ers. The total for this game has changed more dramatically from 49 to 44.5, but you can combine NFL vs. spread picks with NFL over/under bets to make NFL parlay picks for Week 3.
Week 3 NFL spreads and over/unders may still fluctuate, so it’s wise to jump on these NFL lines as soon as possible. Before making any Week 3 NFL picks or NFL parlays, be sure to check out the NFL predictions and betting advice from SportsLine’s proven computer model.
The model has simulated every NFL game 10,000 times and has returned over $7,000 in profits on $100 players on top-tier NFL picks since inception. The model has an astounding 187-130 record on top-tier NFL picks dating back to the 2017 season and going into Week 3 of the 2024 NFL season. It has also gone 41-22 on top-tier NFL picks going forward from Week 7 of 2022.
The model has ranked in the top 10 on NFLPickWatch for straight-up NFL picks four of the last six years and beat over 94% of CBS Sports Football Pick’em players four times during that time, placing it pretty high on anyone who follows it.
Now, the model has thoroughly researched Week 3 NFL odds and confidently identified the five best NFL bets. If you can successfully parlay this model’s selections, you can reap huge payouts of approximately 25 to 1. You can see this model’s Week 3 NFL picks exclusively at SportsLine.
Top NFL picks for Week 3
After simulating each game 10,000 times, the model has the Seattle Seahawks (-4.5, 41.5) more likely to win at home against the Miami Dolphins. Seattle is the only NFC West team with a winning percentage above .500 at 2-0, and Miami has not been competitive against winning teams recently. The Dolphins are 2-11 in their last 13 games against teams with a winning percentage above .500, both straight up and against the spread. Despite the average final spread being Miami (+0.4), the Dolphins’ average margin of defeat is 12.4 points.
Additionally, Miami has lost its last five games against the spread, all of which came with Tua Tagovailoa under center. There’s a big gap between the 2023 passing leaders and undrafted Skylar Thompson, and the model acknowledges that. Thompson is completing less than 60% of his passes and has as many interceptions as he has touchdowns. A hostile road environment will be too much for Miami to overcome, as Seattle is expected to cover more than 50% of the time. See more NFL parlay picks here.
How to make an NFL parlay for Week 3
The model also jumped on four other NFL matchups where the odds were wildly off, including one where the home underdog covered the spread in over 60% of simulations, defying all oddsmakers’ predictions. See the model’s best NFL Week 3 bets and parlays exclusively at SportsLine.
What are the model’s top NFL picks for Week 3, and what other NFL matchups should you target for a 25-to-1 payout? Visit SportsLine now to find out the answers by seeing the model’s best Week 3 NFL bets, which are 187-130 on our top-rated picks.