The Jacksonville Jaguars will face the Buffalo Bills in a key AFC showdown as part of a Monday Night Football doubleheader. Jacksonville needs a win and can’t afford to fall short at 0-3, while Buffalo will be looking to start 3-0 for the first time since going 4-0 in 2020. The Jaguars are 6-8 against AFC opponents since the start of last season. The Bills are 8-5 in the conference since last September.
Kickoff at Highmark Stadium in Orchard Park, New York is scheduled for 7:30 PM ET. The latest Jaguars vs. Bills odds have the Bills favored by 5.5 points, with the over/under for points total at 45.5. Before making any Bills vs. Jaguars picks, be sure to check out the NFL predictions and betting advice from SportsLine’s proven computer model.
The model has simulated every NFL game 10,000 times and has returned over $7,000 in profits on $100 players on top-tier NFL picks since inception. The model has an astounding 187-130 record on top-tier NFL picks dating back to the 2017 season and going into Week 3 of the 2024 NFL season. It has also gone 41-22 on top-tier NFL picks going forward from Week 7 of 2022.
The model has ranked in the top 10 on NFLPickWatch for straight-up NFL picks four of the last six years and beat over 94% of CBS Sports Football Pick’em players four times during that time, placing it pretty high on anyone who follows it.
Now, the model has set its sights on Jaguars vs. Bills and has locked in its predictions, along with its NFL predictions: To see the model’s predictions, visit SportsLine now: Here are some NFL odds for the spread, money line and over/under for Bills vs. Jaguars, as well as NFL betting lines.
Jaguars vs. Bills spread: Buffalo -5.5Jaguars vs. Bills over/under: 45.5 pointsJaguars vs. Bills money line: Buffalo -250, Jacksonville +203JAC: The Jaguars have covered the third quarter spread in 12 of their last 17 games (+6.75 units)BUF: The Bills have hit the third quarter money line in 11 of their last 19 gamesJaguars vs. Bills picks: See picks at SportsLine
Why you should root for the Bills
Wide receiver Khalil Shakir had a team-high five catches for 54 yards last week. He is aiming for three straight games with five or more catches and 50 or more yards. He led the Bills in receiving yards through two games with eight catches for 96 yards (12.0 average) and one touchdown. He had an explosive play that included a 21-yard gain and a 41-yard after-catch catch and five first-down conversions.
Tight end Dalton Kinkaid had four catches for 33 yards in Week 2. He has five catches, 50-plus yards receiving and one touchdown as he looks to play in his third straight primetime game at home. The second-year veteran had 73 receptions for 673 yards (9.2 average) and two touchdowns in 2023. He has five receptions for 44 yards this season. Find out which team to pick here.
Reasons to support the Jaguars
Wide receiver Gabe Davis is coming off three straight games with 40-plus yards receiving and 55-plus yards receiving in two of the last three primetime games. Davis totaled 163 catches for 2,730 yards and 27 touchdowns over four seasons with Buffalo from 2020-2023. This year he has six catches for 105 yards (17.5 average) and five first-down conversions.
Wide receiver Christian Kirk has had four or more catches in four of his last five road games. In his last matchup with Buffalo, he had six catches for 78 yards. Kirk has been playing well under the lights, recording 90-plus yards receiving and a touchdown catch in two of his last three primetime games. He also has 85-plus yards receiving in two of his three career games on Monday Night Football. Find out which team to pick here.
How to predict Jaguars vs Bills
The SportsLine model is leaning toward the Over, projecting a point total of 50. It has also generated an against-the-spread pick that has hit in more than 60 percent of simulations. NFL Model picks are available exclusively at SportsLine.
So who will win the Jaguars vs. Bills matchup on Monday Night Football? And which side of the spread is profitable in over 60% of simulations? Visit SportsLine now to find out which side of the Jaguars vs. Bills spread you should bet on. Find the answers from an advanced model that has made over $7,000 in profits on NFL predictions.
